No7’s new super peptide is set to be one of the most effective and tolerated skincare ingredients on the cosmetic market. Unlike retinoic acid, which is known by dermatologists to cause tolerance challenges such as skin sensitivity and redness, No7’s new super peptide is both highly potent and also highly tolerated, being suitable even for those with sensitive skin. This paves the way to making gold standard skin repair available to even more people.
Cutting-edge Technology
Machine learning was utilised to identify naturally-occurring peptide sequences released from key skin molecules including collagens and elastic-fibre proteins, which were then tested using state-of-the-art omics techniques to characterise their skin remodelling activity and find the most powerful for deep down skin repair.
Scientists evaluated thousands of possible peptide combinations to identify this new super peptide, a blend of two novel synthetic tetra-peptides, pal-GPKG and pal-LSVD, which mimic naturally occurring peptides in the skin to boost the skin’s natural self-repair function.
Robotic technology at the University of Liverpool’s Materials Innovation Factory and mathematical modelling techniques were used to optimise the formulation textures and delivery system for penetration of the peptides to where they are needed and work the best. As a result, penetration is predicted to be 50% better than existing formulations.
The new super peptide technology has been met with excitement from the global scientific community with the technology due to be presented at three world leading scientific conferences this Spring including the American Academy of Dermatology (AAD) Annual Conference in Louisiana, the British Society for Investigative Dermatology (BSID) Annual Meeting in Glasgow and the International Societies for Investigative Dermatology (ISID) meeting in Tokyo.
Dr Matiss Ozols, formerly of The University of Manchester and now based at the Wellcome Sanger Institute, comments: “Application of this peptide discovery pipeline to other tissues could profoundly advance the treatment of age-related diseases, providing novel treatments inspired by the body’s natural self-repair mechanisms. I’m excited by the possibilities!”
This discovery builds on a long history of scientific innovation for No7; the brand was the first to prove that non-medical cosmetic products worked when the scientific efficacy of the No7 Protect and Perfect Serum was verified on BBC Horizon in 2007. In 2009 No7 was the first to publish a 12-month study on an anti-ageing cosmetic product showing clinical wrinkle improvements in a paper published in the British Journal of Dermatology.
Patent applications have been submitted and are pending for both the new peptides and the delivery system.
